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GitHub is home to over 50 million developers working together to host and review code, manage projects, and build software together. Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community. Already on GitHub? Sign in to your account. BrennanConroy – life is about change. Skip to content. Dismiss Join GitHub today GitHub is home to over 50 million developers working together to host and review code, manage projects, and build software together.

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A mix of clouds and sun during the morning will give way to cloudy skies this afternoon. A stray shower or thunderstorm is possible. High 93F. Winds NW at 5 to 10 mph.. Updated: August 24, am. Mitigation includes payments to homeowners, as well as design, construction and monitoring of in-home systems. Remediation includes corrective measures, pilot testing, investigation and the cost of public meetings.

Edit Table Close. Edit Close. Toggle navigation. Tonight Partly cloudy. Low near 55F. Winds S at 5 to 10 mph. Locations Bozeman.

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Deemed. Execution Date, if any. (Month/Day/Year). 3. Transaction. Code (Instr. 8)​. 4. Securities Acquired (A) or. Disposed Of (D) (Instr. 3, 4 and.

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Stacker is highlighting 50 celebrities—in no particular order—and their contributions to the entertainment industry. Billie Joe went mainstream in as the frontman to rock band Green Day. That was when he told The Advocate: ” I think I’ve always been bisexual… I think people are born bisexual, and it’s just that our parents and society kind of veer us off into this feeling of, ‘Oh, I can’t.

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You should never assume you know everything there is to know about a disabled child or adults needs, it is poor practice to offer your services or facilities without some up to date knowledge of the current accepted terminology, law, medical requirements. Understanding the many needs of disabled children and adults is an area that requires careful considerations. If your a committee member, fishery owner, local authority or business the likelihood is that disabled people will want to visit your service.

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LHSAA Executive Director Eddie Bonine said his office has been investigating complaints that schools across the state are working out earlier than the June 8 start date, including two in the Acadiana area. Executive director Eddie Bonine reiterated there will still be no snap judgment on when or if the LHSAA will resume its sports seasons in the wake of the novel coronavirus pandemic.

Bonine said Gov. The order also keeps member schools closed. Edwards’ order also matches federal recommendations made Sunday. That meeting will be conducted remotely.

The BDAA Banquet is Friday, July 30th and the before June 15th to the BDAA Scholarship. Committee input these dates and the group code: bdabdaa.

ABSTRACT This is a proposal to develop a highly selective and potent antiviral benzodiazepine compound against yellow fever virus YFV as a therapeutic agent for treatment of yellow fever and understand its antiviral mechanism. Yellow fever is an acute viral hemorrhagic disease which threatens approximately one billion people living in tropical areas of Africa, Central and South America. Although a highly effective yellow fever vaccine has been available for more than seven decades, the low vaccination rate fails to prevent outbreaks in at-risk regions.

It has been estimated that up to 1. Thus far, there is no specific antiviral treatment for yellow fever. To cope with this medical challenge, we discovered an acetic acid benzodiazepine BDAA compound that potently inhibited YFV replication in both mammalian and insect cells by targeting the viral non-structural 4B NS4B protein. We have already demonstrated in YFV-infected hamsters that oral administration of BDAA significantly protected the animals from death, reduced viral load by greater than 2 logs and attenuated viral infection-induced liver injury and body weight loss.

Building on these encouraging preclinical studies, we propose in this project to optimize the lead compound to obtain benzodiazepine derivatives with improved solubility and reduced plasma protein binding ability to achieve improved in vivo antiviral efficacy and safety profile. Meanwhile, we will continue our efforts toward understanding the molecular mechanism by which BDAA and its derivatives inhibit YFV replication.

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Besides face mask, reusable water bottles are the coolest and most responsible accessory you can own. By shedding the habit, you’ll not only cut out a dubious practice, you’ll also have the chance to to pick out a sharp accessory to bring with you anywhere. The market for reusable water bottles has never been better, with countless companies trying to make the perfect insulated containers and fashion brands seeking to turn them into a statement piece.

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